Achievements

Published by Prof. Agnieszka Chacińska’s team, the ground-breaking research on the cellular response to mitochondrial defects was conducted on the single-celled yeast Saccharomyces cerevisiae. These organisms have served science for decades to study vital processes at the molecular and cellular level. Their culture is not complicated, as they grow rapidly and are estimated to have 23% of the genome identical to humans.

The findings of Prof. Agnieszka Chacińska’s team concerning changes in protein production in the cell in response to mitochondrial defects have been published in the most prestigious scientific journals: Nature, PNAS, Nature Communications and EMBO Molecular Medicine.

Examples of publications

Rearrangements within the U6 snRNA core during the transition between the two catalytic steps of splicing
Eysmont K., Matylla-Kulińska K., Jaskulska A., Magnus M., Konarska M.M.
Molecular Cell, 2019, 75 (3): 538-548.e3
DOI: https://doi.org/10.1016/j.molcel.2019.05.018

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S., Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A.
EMBO Molecular Medicine, 2019, 11(5): e9561
DOI: https://doi.org/10.15252/emmm.201809561

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress
Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A. (2019)
Molecular Biology of the Cell, 2019, 30(15): 1864-1877
DOI: https://doi.org/10.1091/mbc.E18-10-0628

Examples of patent applications and patents

Title
Inhibition of proteolytic activity in the treatment of mitochondriopathies.
Applicant
A. Chacińska, M. Wasilewski, K. Mohanraj
Application number
PCT/EP2019/055068
Filing date
28.02.2019

Published by Prof. Agnieszka Chacińska’s team, the ground-breaking research on the cellular response to mitochondrial defects was conducted on the single-celled yeast Saccharomyces cerevisiae. These organisms have served science for decades to study vital processes at the molecular and cellular level. Their culture is not complicated, as they grow rapidly and are estimated to have 23% of the genome identical to humans.

The findings of Prof. Agnieszka Chacińska’s team concerning changes in protein production in the cell in response to mitochondrial defects have been published in the most prestigious scientific journals: Nature, PNAS, Nature Communications and EMBO Molecular Medicine.

Examples of publications

Rearrangements within the U6 snRNA core during the transition between the two catalytic steps of splicing
Eysmont K., Matylla-Kulińska K., Jaskulska A., Magnus M., Konarska M.M.
Molecular Cell, 2019, 75 (3): 538-548.e3
DOI: https://doi.org/10.1016/j.molcel.2019.05.018

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S., Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A.
EMBO Molecular Medicine, 2019, 11(5): e9561
DOI: https://doi.org/10.15252/emmm.201809561

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress
Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A. (2019)
Molecular Biology of the Cell, 2019, 30(15): 1864-1877
DOI: https://doi.org/10.1091/mbc.E18-10-0628

Examples of patent applications and patents

Title
Inhibition of proteolytic activity in the treatment of mitochondriopathies.
Applicant
A. Chacińska, M. Wasilewski, K. Mohanraj
Application number
PCT/EP2019/055068
Filing date
28.02.2019