Loss of chromosome Y and human disease (LOY)
THE SCOPE OF THE RESEARCH
Dumanski’s group in IRAP is devoted to the research on association between LOY (Loss of Chromosome Y) in peripheral blood and higher risk of cancer and AD in aging men. Our ultimate goal is to develop LOY-based screening approach for the assessment of non-hereditary cancer and neurodegeneration risk, years before first clinical symptoms become apparent. We are aiming to unravel the functional mechanisms of LOY in the process of disease development. We will analyze selected populations of peripheral blood leukocytes, tumor infiltrating and brain immune cells as well as cell culture models. We will use state-of-the-art methodology including cell sorting, high dimensional flow cytometry, laser microdissection, genotyping microarrays, massively parallel sequencing of DNA, bulk RNA- and single cell RNA-seq, spatial transcriptomics. The resulting wet-lab data will be subjected to advanced bioinformatic and biostatistical analysis.