THE SCOPE OF THE RESEARCH
We are interested in cellular responses to environmental stimulations in the context of their genetic, epigenetic, and environmental background. We use high-throughput approaches to study cell transitions, cell-cell communications, and chromatin transformations. In particular in cancer cells to provide diagnostic and therapeutic solutions. Our key focus is using computational and experimental approaches to dissect, model, and interrogate changes in chromatin structure and gene expression regulations triggered by genetic modifications and/or extracellular stimulations. We pursue multi-disciplinary projects aiming to uncover patterns in chromatin and gene expression profiles relating to the cell state.