The centre is implementing a project entitled: „Mutations acquired during lifetime that lead to increased risk for human disease, with focus on cancer.” Researchers at the 3P Medicine Laboratory are focusing especially on the development of breast cancer in women, prostate cancer in men, and colon and bladder cancers in both genders, and also Alzheimer’s disease in men related to their loss of chromosome Y in leucocytes. Results of this research could lead to the identification of new cancer risk biomarkers and help better understand early stages of Alzheimer’s disease.

Project Creators

Prof. Jan Dumanski
Prof. Jan Dumanski
He studied medicine at the Jagiellonian University in Krakow, Poland. Began research in 1986 at the Karolinska Institutet in Stockholm, Sweden. There he obtained his doctorate and in 2000 received the title of professor at Uppsala University in Sweden, in the field of Experimental Pathology, at the Department of Immunology, Genetics and Pathology. He was also a professor at the University of Alabama in Birmingham, USA, where he headed the Howell and Elizabeth Heflin Center for Human Genetics. He participated in many international research projects on cancer genetics, the molecular basis of metastasis, or the mechanisms behind cancer predisposition. One of his current main research interests is the loss of the Y chromosome (LOY) in male leukocytes and contributing to the development of many diseases, including cancer and Alzheimer’s disease.
Prof. Arkadiusz Piotrowski
Prof. Arkadiusz Piotrowski
Graduate of the IntercollegiateFaculty of Biotechnology, University of Gdańsk, and the Medical University of Gdańsk (GUMed). He earned his PhD in Pharmacy from the Faculty of Pharmacy and Department of Laboratory Medicine at GUMed. Following his doctorate, he worked at the Department of Immunology, Genetics and Pathology, Uppsala University, Sweden, and at the Department of Genetics, University of Alabama, Birmingham, USA. He continues to be affiliated with UAB as Adjunct Professor, and also carries out international research projects (including a grant from the US Department of Defense). His principal field of research is somatic mosaicism and structural rearrangements of the genome in the context of cancers and rare genetic diseases.
Strategic Partner

Uppsala University
International scientific partners

Single Molecule Genetics, Institute of Biophysics, Johannes Kepler University Linz
Linz, Austria
Institut Mondor de Recherche Biomédicale, INSERM
Paris, France
Genomics Core Lab, Heflin Center for Genomic Science, University of Alabama at Birmingham
Birmingham, USA
Clinical Genomics Research Group, Program of Predictive and Personalized Medicine of Cancer (PMPPC), Germans Trias i Pujol Research Institute (IGTP)
Barcelona, Spain
Polish scientific and clinical partners

Oncology Center – Prof. Franciszek Łukaszczyk Memorial Hospital
Maria Skłodowska-Curie National Research Institute of Oncology
University Clinical Centre in Gdańsk
University Hospital in Cracow
Specialist Hospital of Kościerzyna
Department of Clinical Immunology, Jagiellonian University
Department of Internal Medicine and Gerontology, Jagiellonian University
Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology of the Polish Academy of Sciences
Institute of Human Genetics, Polish Academy of Sciences

Prof. Ulf Landegren
Uppsala University (Sweden)
Prof. Carl-Henrik Heldin
Uppsala University, Ludwig Institute for Cancer Research (Sweden)
Prof. Constantin Polychronakos
McGill University, Montreal (Canada)
Prof. Joris Vermeesch
KU Leuven (Belgium)
Prof. Peter Campbell
Wellcome Trust Sanger Institute, Hinxton (UK)
Prof. Devin Absher
Hudson Alpha Institute for Biotechnology, Huntsville (USA)
Prof. Floris Fijer
University of Groningen (the Netherlands)
Prof. Jan Korbel
European Molecular Biology Laboratory, Heidelberg (Germany)
Prof. John Armour
University of Nottingham (UK)
Prof. Nils-Goran Larsson
Max Planck Institute for Biology of Ageing, Cologne (Germany)
Prof. Wojciech Zegarski
Oncology Centre, Bydgoszcz (Poland)
Prof. Andrzej Mackiewicz
Poznan University of Medical Science, Poznan (Poland)
Foreign partners

Uppsala University
Uppsala University (Sweden)