THE IMPACT OF UPF1 ATP MIMETICS ON THE MUTANT IMMUNOPEPTIDOME – A NEW OPUS PROJECT AT ICCVS
About the research: A critical cellular surveillance mechanism that recognizes and eliminates aberrant mRNAs containing premature termination codons (PTC) is termed as nonsense-mediated mRNA decay (NMD). PTCs containing mRNAs are rapidly degraded by the NMD machinery. Active NMD renders many dominant mutations recessive by degrading transcripts encoding abnormal proteins with dominant activities. By this mechanism, NMD can exacerbate the phenotypes